What is the pediatric dosage of Zofran for nausea/vomiting?

The pediatric dosage of Zofran (ondansetron) for the treatment of nausea and vomiting is indeed 0.1 mg/kg administered either intramuscularly or through slow intravenous/intraosseous injection. This dosage can be repeated in 10-minute intervals, with a maximum total dose of 8 mg for patients who weigh 40 kg or more. This approach is designed to effectively manage nausea and vomiting while also taking safety and efficacy into account for older children or those with higher body weight.

The rationale behind the specified maximum dose and the frequency of administration has to do with balancing therapeutic effects against potential side effects. For pediatric patients, proper dosage calculation based on weight is critical for safety. Administering excessive amounts can lead to adverse effects, which is why the protocol ensures a repeat dose is contingent upon the patient's weight.

In contrast, the other options either provide incorrect dosing amounts that deviate from established guidelines or suggest routes of administration that may not be standard for this situation. Each of these factors highlights the importance of adhering to recommended protocols to ensure the safety and efficacy of treatment in pediatric emergency care.