What is the ideal dose for administration via MAD?

The ideal dose for administration via a mucosal atomization device (MAD) is typically in the range of 0.3mL to 0.5mL per nostril. This dosage is optimal because it balances effective delivery of the medication while minimizing waste and ensuring proper absorption through the mucosal membranes in the nasal cavity.

Administering too high a volume could lead to problems such as overflow or difficulty in absorption, where the medication may not be adequately retained in the nasal passages. In contrast, doses lower than this range might not provide sufficient therapeutic effect.

This rationale is grounded in the pharmacokinetics of intranasal medications, where the goal is to achieve a rapid onset of action through the rich blood supply in the nasal mucosa, making the 0.3mL to 0.5mL range the most effective for achieving these therapeutic outcomes.