What is the dosage of Magnesium Sulfate for severe asthma treatment?

In the management of severe asthma exacerbations, magnesium sulfate serves as a bronchodilator, particularly in cases that do not respond adequately to conventional treatments like beta-agonists and corticosteroids. The recommended dosage for magnesium sulfate in this scenario is 2 grams administered intravenously or intraosseously over a period of 10 minutes. This specific dosing is based on clinical guidelines that highlight the effectiveness of magnesium sulfate in relaxing bronchial smooth muscle and reducing inflammation in patients experiencing severe respiratory distress.

Administering 2 grams allows for achieving optimal therapeutic levels to exert its bronchodilatory effects while minimizing potential side effects that could arise from higher dosages. The timeframe of 10 minutes is also significant as it enables the medication to circulate effectively, thereby providing relief in acute episodes of severe asthma.

Other options reflect differing amounts and routes that do not align with established protocols for this specific clinical presentation, hence they are not appropriate for the treatment of severe asthma exacerbations as recommended by emergency medicine guidelines.