What is the dosage of Epinephrine for severe asthma not responding to initial treatment?

The appropriate dosage of Epinephrine for severe asthma that is not responding to initial treatment is 0.3 mg IM (1:1,000), which can be repeated up to two times every five minutes. This dosing is aligned with established protocols for managing severe asthma exacerbations where quick and effective bronchodilation is critical.

Epinephrine acts rapidly on the adrenergic receptors, leading to bronchodilation and improved respiratory status. The IM route allows for a faster onset of action compared to oral or subcutaneous routes, making it particularly effective in emergency situations.

The recommendation to repeat the dosage two times within a five-minute interval is significant. It ensures that the patient receives adequate support to overcome life-threatening airway constriction while avoiding adverse cardiovascular effects by not exceeding the recommended limits. This structured approach to dosing balances efficacy with safety, which is crucial in acute management scenarios for asthma.