What drug may interact with nitroglycerin if used within 24 to 48 hours?

The interaction between nitroglycerin and Viagra, which contains the active ingredient sildenafil, is significant and well-documented. Both nitroglycerin and Viagra are vasodilators, meaning they relax and widen blood vessels. When taken together, they can cause a profound drop in blood pressure, leading to serious cardiovascular complications, including fainting, heart attack, or stroke.

This is particularly concerning because the effects of Viagra can last for several hours, and when combined with nitroglycerin within a 24 to 48-hour window, the risk of hypotension is heightened. Medical guidelines emphasize that patients taking Viagra should avoid nitroglycerin and other nitrate medications for at least 24 hours after taking Viagra to ensure safety and prevent potentially dangerous interactions.

In contrast, while other medications listed may have their own considerations in the context of treating patients, they do not have the same high-risk interaction with nitroglycerin as Viagra does.